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| 1. | To suffer a major setback due to carelessness |
| 大意失荆州 |
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| 2. | Even when he was flat broke after a major financial setback, he continued to refer to himself as a rich |
| 他拒绝某事时会这样说：“我是一个富人，而富人从不这么做”，甚至当一次严重的挫折使他破产后，他仍然把自己当作是富人。 |
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| 3. | When anything goes this well, a major setback can be just around the corner. |
| 一件事过于顺利的时候，很可能不久就会有大挫折。 |
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| 4. | The reformists attribute the major setback in elections suffered by the MDP on the 13th to the scandals |
| 改革派人士将新千年民主党在十三日选举的重大挫败归罪于金大中的助理和儿子涉及的丑闻，如今他们希望成立一个新的政党。 |
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| 5. | Another major setback for the labor movement occurred in 1905 with the Supreme Court ruling in the case |
| １９０５年最高法院对“洛克纳诉纽约案”作出裁决，使劳工运动遭受到另一次重大挫折。 |
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| 6. | Even when he was flat broke after a major financial setback, he continued to refer to himself as a rich |
| 他会这样说:"我是一个富人,而富人从不这么做",甚至当一次严重的挫折使他破产后,他仍然把自己当作是富人。 |
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